The ubiquitin-proteasome system (UPS) orchestrates targeted protein degradation and remodelling in mammalian sperm, underpinning functional maturation, fertilisation and post-fertilisation events. In ...

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...

Recent research from the lab of Dr. Nicolas Lehrbach, an Assistant Professor in the Basic Sciences Division at Fred Hutch, discovered that altering nucleotide metabolism may bypass proteasome defects ...