Advances in structural biology have allowed scientists to determine molecular structures with atomic-level detail, sometimes yielding static snapshots that do not reflect the dynamism of proteins.

Distal mutations, though far from the active site, enhance Kemp eliminase catalysis by tuning conformational dynamics that facilitate substrate binding and product release, thereby promoting the full ...

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their study, published in Nature Communications, sheds new light on the interplay ...

Messenger RNA is vital to cells, and now scientists have discovered a critical new role for this crucial molecule.. | ...

Researchers discover that Alzheimer's-linked APP protein protects neurons by clearing toxic leaked nuclear waste via ...

Some proteins in human cells that are implicated in cancer also have causal roles in neurodevelopmental disorders, raising the possibility of repurposing targeted cancer therapies to help address ...

Researchers at Niigata University's Brain Research Institute have uncovered a new function of amyloid precursor protein (APP) ...

Proteins, the pillars of cellular function, often assemble into 'complexes' to fulfill their functions. A study reveals why this assembly often begins during the very process of protein synthesis or ...

Proteomics is the large-scale study of proteins, particularly their structures and functions. It involves the systematic identification, quantification, and analysis of the entire protein complement ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...