In this original study, Inage et al. developed a mouse model to ablate nephron progenitor cells during embryonic day 13.5 of gestation without significantly affecting birth weight or other organ ...

The proximal tubules (PTs) of the kidney represent a highly specialised portion of the nephron performing the bulk of kidney reabsorption and secretion. This occurs via three distinct functional and ...

“You’re on a chemotherapeutic and your oncologist may say that your dosage is X, while a nephrologist is telling you that the proximal tubules in your kidneys can’t handle it. You’re harming them.” ...