OBJECTIVE: To determine the effect of weight loss and exercise interventions on serum leptin and to investigate the relationship of physical function and osteoarthritis (OA) severity with serum leptin ...

Leptin, a hormone produced chiefly by adipose tissue, plays a central role in coordinating energy balance, immune responses and vascular homeostasis. Beyond its well-characterised functions in ...

A unique technique for neutralizing the action of the leptin protein in humans and animals – thereby providing a means for controlling and better understanding of leptin function, including its role ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic ...

The hormone leptin reduces food intake, in part, by activating the hippocampus, an area of the brain that controls learning and memory function, according to new research. Researchers found that when ...

CINCINNATI—The hormone leptin, typically associated with body weight regulation, works within the central nervous system (CNS) to aid the immune system's defense against sepsis, researchers say.

How Does Leptin Regulate Hunger? When the leptin levels drop due to fasting, the brain signals the body that fat stores are low and we must eat. This is called the negative feedback loop. Circulating ...

The spectrum of the known physiological processes controlled by leptin is quite broad; still, some of the leptin functions are only just being recognized. Consequently, the list of leptin-related ...

2014 marks the 20th anniversary of the discovery of leptin – the hormone that tells our brains when we've eaten enough and the first reported genetic basis for obesity. The discovery will be ...

In 2005 the World Health Organization (WHO) estimated that globally 400 million adults were obese, defined by a body mass index (BMI) of 30 kg/m2 or greater. WHO projects that by 2015 there will be ...

Ultrasonographic examinations during pregnancy were considered normal except for suspected macrosomia in the third trimester. The patient's total weight gain during pregnancy was 50 kg (110 lb) from a ...