本研究揭示了 Cryptococcus neoformans fbp1Δ 疫苗的免疫原性机制，发现胶囊和Cytokine Inducing Glycoprotein 1（Cig1）蛋白共同参与疫苗诱导的Th1免疫应答，Cig1作为Fbp1 E3连接酶的底物，其过表达增强疫苗效果，而Cig1缺失导致保护性免疫减弱，为优化真菌疫苗提供了新靶点。

Ultimately, the goal is to find ways to stop deadly disease caused by Cryptococcus neoformans from developing in humans and animals. But until that time, finding new and better ways to treat already ...

Ultimately, the goal is to find ways to stop deadly disease caused by Cryptococcus neoformans from developing in humans and animals. But until that time, finding new and better ways to treat already ...

Cryptococcus neoformans is a fungal pathogen that infects people with weakened immune systems, particularly those with advanced HIV/AIDS. New research could mean a better understanding of this ...

A new study has uncovered how serious fungal infections grow in humans by conserving phosphate, highlighting a possible target for treatment. A new study from The Westmead Institute for Medical ...

Figure 3. Pre-activation of alveolar-like macrophages with IFN-γ and MTb cues reduces their capacity to restrict C. neoformans growth. Cryptococcus neoformans is one of four fungi classified as ...

Bacterial and viral are the more prevalent and commonly discussed forms of meningitis, but one infectious disease expert at the University of Alabama at Birmingham says fungal meningitis stemming from ...

What is Cryptococcus, who does it affect and how many people does it kill each year? Cryptococcus is a fungus found in the environment throughout the world that is able to cause disease in humans.

The world is filled with tiny creatures that find us delicious. Bacteria and viruses are the obvious bad guys, drivers of deadly global pandemics and annoying infections. But the pathogens we haven't ...