生物通

综述：基于Cereblon的PROTACs的合成、生物学评价及临床试验

这篇综述全面评述了基于Cereblon的蛋白降解靶向嵌合体(PROTACs)研究进展，涵盖其结构功能、配体设计、合成策略及临床转化 ...

Reversing T cell exhaustion improves effectiveness of myeloma immunotherapies

Researchers at the Icahn School of Medicine at Mount Sinai, Bristol Myers Squibb, and the University of Oxford have ...
BioWorld

St. Jude Children’s Research Hospital presents new modulators of GSPT1 and/or IKZF1 activity

St. Jude Children’s Research Hospital has divulged molecular glue degraders comprising cereblon (CRBN) binding agents covalently bound to a eukaryotic peptide chain release factor GTP-binding subunit ...
Medscape

Iberdomide Shows Promise for Cutaneous Lupus in Phase 2 Study

Patients with cutaneous lupus erythematosus (CLE) experienced improved symptoms with iberdomide, a cereblon modulator, added to standard lupus medications, particularly in subacute and chronic cases. ...
Healio

Only highest-dose iberdomide outperforms placebo in SLE; adverse events high

Please provide your email address to receive an email when new articles are posted on . Iberdomide, a novel oral cereblon modulator, was superior to a placebo only in patients with systemic lupus ...
Cure Today

First-in-Human Trial of Novel Therapy Shows Promising Results in Relapsed/Refractory ...

CC-92480, a novel cereblon E3 ligase modulator agent, in combination with dexamethasone appeared safe and active in patients with heavily pretreated relapsed or refractory multiple myeloma, according ...
BioWorld

Items Tagged with 'modulators of GSPT1 and/or IKZF1 activity'

St. Jude Children’s Research Hospital has divulged molecular glue degraders comprising cereblon (CRBN) binding agents covalently bound to a eukaryotic peptide chain release factor GTP-binding subunit ...