引言如果一个基因被敲掉后，肿瘤更容易转移，我们通常会问：这个基因调控了什么通路？但随之也出现了一个更难、也更接近真实生命过程的问题：这个基因是在组织里的哪个位置发挥作用？5月26日，《Cell》的研究报道“Uncovering spatially ...

CRISPR screens generate actionable insights for drug discovery—explore how to optimize a screen, how to avoid pitfalls, and ...

Amanda McQuade and Nathaniel Robichaud discuss how integrated proteomic and transcriptomic profiling can reveal cellular responses to genetic perturbations that are not captured through RNA analysis ...

The brain is often referred to as a "black box"—one that's difficult to peer inside and determine what's happening at any given moment. This is part of the reason why it's difficult to understand the ...

Over the past few decades, biomedical researchers and neuroscientists have devised increasingly advanced techniques to study and alter neurophysiological processes. These include CRISPR (Clustered ...

Revvity's Dharmacon All-in-one lentiviral platform has expanded to include whole-genome library options for CRISPR knockout (CRISPRko), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa).

The brain is often referred to as a "black box" - one that's difficult to peer inside and determine what's happening at any given moment. This is part of the reason why it's difficult to understand ...

Researchers at Columbia University’s Sadelain lab and University Hospital Tubingen used CRISPR gene editing to knock out the ...

Scientists from Mass General Brigham and the Broad Institute of MIT and Harvard have used CRISPR screens to identify genetic modifications that influence T cell function and survival in cultures and ...